LSD1/ER-IN-1

CAT: 0804-HY-146440Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-146440Size:1 Each

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Description

LSD1/ER-IN-1 (compound 11g) is a potent ER and LSD1 inhibitor, with an IC50 of 1.55 μM (LSD1) . LSD1/ER-IN-1 has high affinity selectivity for ERα protein, with α/β ratio of 7.11. LSD1/ER-IN-1 shows good antiproliferative activity against MCF-7 breast cancer cells, with an IC50 of 8.79 μM[1].

UNSPSC

12352005

Target

Apoptosis; Estrogen Receptor/ERR; Histone Demethylase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lsd1-er-in-1.html

Solubility

10 mM in DMSO

Smiles

O=S(C1[C@H]2C(C3=CC=C(O)C=C3)=C(C4=CC=C(O)C=C4)[C@@H](C1)O2)(OC5=NC(F)=CC=C5)=O

Molecular Formula

C23H18FNO6S

Molecular Weight

455.46

References & Citations

[1]He M, et al. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer. Eur J Med Chem. 2020 Jun 1;195:112281.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERα; ERβ; KDM1/LSD1

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