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MAGL-IN-22

CAT: 0931-T212430-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212430-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2720674-71-3
Target
Nrf2, MAGL, NF-κB
Related Pathways
Metabolism, Immunology/Inflammation, NF-κB
Bioactivity
MAGL-IN-22 (Compound 40) is a reversible, competitive, and selective inhibitor of MAGL that is capable of crossing the blood-brain barrier, with an IC50 of 0.34 μM for hMAGL. It exhibits significant antioxidant and anti-inflammatory properties, activating the Nrf2 pathway and markedly suppressing NFκB-mediated inflammation, without inducing cytotoxic effects. MAGL-IN-22 is applicable in research on neurodegenerative diseases, chronic pain, and cancer.
Smiles
O=C(NC1=CC(=CC=C1O)C=2C=CC(O)=C(F)C2)CCCC=3C=CC=CC3
Molecular Formula
C22H20FNO3
Molecular Weight
365.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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