LXR agonist 2

CAT: 0804-HY-146288Size: 1 EachDry Ice: NoHazardous: No

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Description

LXR agonist 2 (compound 18rr) is a potent LXR (liver X receptor) agonist. LXR agonist 2 can stabilize NCOA1 (co-activator), leading to LXR agonism[1].

CAS Number

2978788-07-5

UNSPSC

12352005

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lxr-agonist-2.html

Solubility

10 mM in DMSO

Smiles

CC([C@H]1N(CC[C@]12C(N(C3=C2C=CC=C3)C4=CC=CC(C5=CC=C(C(Cl)=C5)C(N(C)C)=O)=C4)=O)C(CC(C)(C)C)=O)C

Molecular Formula

C35H40ClN3O3

Molecular Weight

586.16

References & Citations

[1]Chen Z, et al. Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors. Eur J Med Chem. 2020 Nov 15;206:112793.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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LXR agonist 2

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