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AChE-IN-14

CAT: 0804-HY-146035Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146035Size:1 Each
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Description
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46, 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM) . AChE-IN-14 can be used for the research of Alzheimer’s disease[1].
CAS Number
2390042-05-2
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C2=CC=C(OCCCCCCN3CCCCCC3)C=C2)OC4=CC=C(C)C=C14
Molecular Formula
C28H35NO3
Molecular Weight
433.58
References & Citations
3
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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