5-HT6/5-HT2AR antagonist-1

• UNSPSC Description:

  5-HT6/5-HT2AR antagonist-1 is a potent dual 5-HT6/5-HT2AR antagonist with Ki values of 11 nM and 39 nM, respectively[1].

• Target Antigen:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/5-ht6-5-ht2ar-antagonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC(N2CCN(C)CC2)=NC(C(C)(SC3=CC=C4C=CC=CC4=C3)C)=N1

• Molecular Weight:

  394.54

• References & Citations:

  [1]Katarzyna Kucwaj-Brysz, et al. An exit beyond the pharmacophore model for 5-HT 6 R agents - a new strategy to gain dual 5-HT 6/5-HT 2A action for triazine derivatives with procognitive potential. Bioorg Chem. 2022 Apr;121:105695.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2763654-60-8