5-HT6/5-HT2AR antagonist-1

5-HT6/5-HT2AR antagonist-1

• CAS Number: 2763654-60-8
• UNSPSC Description: 5-HT6/5-HT2AR antagonist-1 is a potent dual 5-HT6/5-HT2AR antagonist with Ki values of 11 nM and 39 nM, respectively[1].
• Target Antigen: 5-HT Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/5-ht6-5-ht2ar-antagonist-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=NC(N2CCN(C)CC2)=NC(C(C)(SC3=CC=C4C=CC=CC4=C3)C)=N1
• Molecular Weight: 394.54
• References & Citations: [1]Katarzyna Kucwaj-Brysz, et al. An exit beyond the pharmacophore model for 5-HT 6 R agents - a new strategy to gain dual 5-HT 6/5-HT 2A action for triazine derivatives with procognitive potential. Bioorg Chem. 2022 Apr;121:105695.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported