5-HT6 agonist 1

• UNSPSC Description:

  5-HT6 agonist 1 (Compound 19) is a 5-HT6 agonist (Ki: 5 nM). 5-HT6 agonist 1 has antidepressant-like properties, and improves cognitive deficits. 5-HT6 agonist 1 also inhibits platelet aggregation. 5-HT6 agonist 1 has high metabolic stability[1].

• Target Antigen:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/5-ht6-agonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC(C1=NC(N)=NC(N2CCN(C)CC2)=N1)SC3=C(Cl)C=CC(Cl)=C3

• Molecular Weight:

  413.37

• References & Citations:

  [1]Czarnota-Łydka K, et al. Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease. Eur J Med Chem. 2023 Nov 5;259:115695.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported