5-HT6 inverse agonist 1

• UNSPSC Description:

  5-HT6 inverse agonist 1 (Compound 33) is an antagonist for 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. 5-HT6 inverse agonist 1 inhibits the 5-HT6R mediated Cdk5 and mTOR signaling pathway. 5-HT6 inverse agonist 1 reduces tactile hypersensitivity in spinal nerve ligation (SNL)-induced rat model[1].

• Target Antigen:

  5-HT Receptor; CDK; mTOR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;GPCR/G Protein;Neuronal Signaling;PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/5-ht6-inverse-agonist-1.html

• Smiles:

  O=C(NC1CCNCC1)C2=C(N(C=C2)S(=O)(C3=CC=CC(Cl)=C3)=O)C4=CC=C(C=C4)F.Cl

• Molecular Weight:

  498.40

• References & Citations:

  [1]Drop M, et al., Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide. Bioorg Chem. 2021 Oct;115:105218.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2727088-38-0