5-HT6 inverse agonist 1

5-HT6 inverse agonist 1

• CAS Number: 2727088-38-0
• UNSPSC Description: 5-HT6 inverse agonist 1 (Compound 33) is an antagonist for 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. 5-HT6 inverse agonist 1 inhibits the 5-HT6R mediated Cdk5 and mTOR signaling pathway. 5-HT6 inverse agonist 1 reduces tactile hypersensitivity in spinal nerve ligation (SNL)-induced rat model[1].
• Target Antigen: 5-HT Receptor; CDK; mTOR
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;GPCR/G Protein;Neuronal Signaling;PI3K/Akt/mTOR
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/5-ht6-inverse-agonist-1.html
• Smiles: O=C(NC1CCNCC1)C2=C(N(C=C2)S(=O)(C3=CC=CC(Cl)=C3)=O)C4=CC=C(C=C4)F.Cl
• Molecular Weight: 498.40
• References & Citations: [1]Drop M, et al., Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide. Bioorg Chem. 2021 Oct;115:105218.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported