AAK1-IN-4

• Target :

  Others|||AAK1 (AP2 associated kinase 1)

• Related Pathways :

  Others|||Neuroscience

• Bioactivity :

  AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degree of selectivity with an AAK1 inhibitory concentration (IC50) of 4.6 nM, a Filt dissociation constant (Ki) of 0.9 nM, and a cellular IC50 of 8.6 nM. AAK1-IN-4 holds promise as a valuable tool in the investigation of neuropathic pain [1].

• Smiles :

  CC1=NC(=CC=C1OC[C@@](CC(C)C)(C)N)C=2C=C(NC(OC)=O)N=CC2

• Molecular Formula :

  C20H28N4O3

• Molecular Weight :

  372.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1815612-79-3