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AAK1-IN-4

CAT: 0931-T61499-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61499-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1815612-79-3
Target
Others, AAK1 (AP2 associated kinase 1)
Related Pathways
Others, Neuroscience
Bioactivity
AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degree of selectivity with an AAK1 inhibitory concentration (IC50) of 4.6 nM, a Filt dissociation constant (Ki) of 0.9 nM, and a cellular IC50 of 8.6 nM. AAK1-IN-4 holds promise as a valuable tool in the investigation of neuropathic pain [1].
Smiles
CC1=NC(=CC=C1OC[C@@](CC(C)C)(C)N)C=2C=C(NC(OC)=O)N=CC2
Molecular Formula
C20H28N4O3
Molecular Weight
372.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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