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BAY 1214784

CAT: 0804-HY-144863-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144863-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R) . BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids[1].
CAS Number
1631164-25-4
UNSPSC
12352005
Target
GnRH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-1214784.html
Purity
99.8
Solubility
DMSO : 42 mg/mL (ultrasonic; warming)
Smiles
O=S(N1[C@@](C2CC2)([H])C3(CCS(=O)(CC3)=O)C4=CC(C(NCC5=C(C=C(C=N5)C(F)(F)F)Cl)=O)=CC=C41)(C6=CC=C(C=C6)F)=O
Molecular Formula
C29H26ClF4N3O5S2
Molecular Weight
672.11
References & Citations
[1]Panknin O, et al. Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women. J Med Chem. 2020;63 (20) :11854-11881
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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