BAY-364

• Description :

  BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34+ cells and K562 cells with IC50 values of 1.0 µM, 10.4 µM and 10.0 µM respectively[1].

• Product Name Alternative :

  BAY-299N

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bay-364.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NC2=CC(N3C(C4=CC=CC5=C4C(C3=O)=CC=C5CCCO)=O)=CC=C2N1C

• Molecular Formula :

  C23H19N3O4

• Molecular Weight :

  401.41

• References & Citations :

  [1]Xu Y, et al. TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Nat Commun. 2019 Oct 29;10 (1) :4925. |[2]Garcia-Carpizo V, et al. Therapeutic potential of TAF1 bromodomains for cancer treatment[J]. bioRxiv, 2018: 394254.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2097610-30-3]