Tubulin polymerization-IN-4
CAT:
804-HY-144786
Size:
Inquire
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tubulin polymerization-IN-4
- CAS Number: 2835559-00-5
- UNSPSC Description: Tubulin polymerization-IN-4 is a potent tubulin polymerization inhibitor with IC50 value of 4.6 μM. Tubulin polymerization-IN-4 can disrupt tubulin polymerization and vasculature, arrest the cell cycle at the G2/M phase, induce apoptosis, and suppress clonogenesis and migration in HeLa cells. Tubulin polymerization-IN-4 can be used for researching cervical cancer[1].
- Target Antigen: Apoptosis; Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-4.html
- Solubility: 10 mM in DMSO
- Smiles: CCOC1=CC=C(C=C1Cl)C2=C(N=CN=C2)C3=CC(OC)=C(C(OC)=C3)OC
- Molecular Weight: 400.86
- References & Citations: [1]Huo Z, Liu K, Zhang X, Liang Y, Sun X. Discovery of pyrimidine-bridged CA-4 CBSIs for the treatment of cervical cancer in combination with cisplatin with significantly reduced nephrotoxicity. Eur J Med Chem. 2022;235:114271.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported