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AChE-IN-10

CAT: 0804-HY-144775Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144775Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM) . AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE[1].
CAS Number
2770832-90-9
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-10.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(CC(CC3CCN(CC3)CC4=CC=CC(F)=C4)(S2(=O)=O)F)=C1)OC
Molecular Formula
C23H27F2NO4S
Molecular Weight
451.53
References & Citations
[1] Liu Y, et al. Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 May 5;235:114305.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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