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LSD1-IN-12

CAT: 0804-HY-144673Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144673Size:1 Each
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Description
LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively[1].
CAS Number
1228143-76-7
UNSPSC
12352005
Target
Histone Demethylase; Monoamine Oxidase
Type
Reference compound
Related Pathways
Epigenetics; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-in-12.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]1C[C@H]1C2=CC=C(C=C2)NC(C3=CC=CC=C3)=O
Molecular Formula
C16H16N2O
Molecular Weight
252.31
References & Citations
[1]Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65 (5) :4335-4349.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1; MAO-A; MAO-B

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