LSD1-IN-12

• Description:

  LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively[1].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@@H]1C[C@H]1C2=CC=C(C=C2)NC(C3=CC=CC=C3)=O

• Molecular Formula:

  C16H16N2O

• Molecular Weight:

  252.31

• References & Citations:

  [1]Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65 (5) :4335-4349.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  KDM1/LSD1; MAO-A; MAO-B

• CAS Number:

  [1228143-76-7]