P-gp/BCRP-IN-2

CAT: 0804-HY-155152Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-155152Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

P-gp/BCRP-IN-2 (compound 15) is an oxadiazole derivative and a dual inhibitor of the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). P-gp/BCRP-IN-2 also enhances the anti-proliferative effects of Doxorubicin in drug-resistant human adenocarcinoma colon cancer cell lines HT29/DX and MDCK-MDR1 cells[1].

UNSPSC

12352005

Target

BCRP; P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p-gp-bcrp-in-2.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(/C=C/C2=NN=C(O2)C(C=C3)=CC=C3CCN4CCC5=CC(OC)=C(OC)C=C5C4)=CC(OC)=C1OC

Molecular Formula

C32H35N3O6

Molecular Weight

557.64

References & Citations

[1]Braconi L, et al. Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers. Eur J Med Chem. 2023 Nov 5;259:115716..

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-144393	P-gp/BCRP-IN-1
HY-146117	P-gp modulator 2
HY-N144114	P-gp inhibitor 2
HY-174324	VEGFR-2/P-gp-IN-1
HY-175522	P-gp-IN-31
HY-175206	P-gp-IN-30
HY-175838	P-gp-IN-32
HY-169860-01	BCRP-IN-2
HY-178349	P-gp inhibitor 30
HY-157484	P-gp inhibitor 19

Alternative Products

Catalog	Name
GTR19231135-01	P-gp/BCRP-IN-2
MBS5805938	P-gp/BCRP-IN-1
T63032-01	P-gp modulator 2
T72739-01	P-gp inhibitor 2
GTR19241144-01	BCRP-IN-2
T211172-01	VEGFR-2/P-gp-IN-1
T212471-01	P-gp-IN-31
GTR19272890-01	P-gp-IN-32
T211609-01	P-gp-IN-30
GTR19273727-01	P-gp-IN-33

P-gp/BCRP-IN-2

Related Products

Alternative Products

Popular Products