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CDK2/PIM1-IN-1

CAT: 0804-HY-173224Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173224Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK2/PIM1-IN-1 is an inhibitor of CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM) kinases. CDK2/PIM1-IN-1 induces apoptosis and reduces tumor-promoting TNF-α expression. CDK2/PIM1-IN-1 has antitumor activity[1].
UNSPSC
12352005
Target
CDK; Pim
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling
Field of Research
Cancer
Smiles
COC1=CC=C(C2=CC=NC3=C2C(C4=CC=C(C)C=C4)=NN3C5=CC=CC=C5)C=C1OC
Molecular Formula
C27H23N3O2
Molecular Weight
421.49
References & Citations
[1]Elkotamy MS, et al. Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as dual CDK2/PIM1 inhibitors with potent anti-cancer activity and selectivity. J Biomol Struct Dyn. 2025 Mar 13:1-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; PIM1

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