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HPK1-IN-29

CAT: 0804-HY-143870Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143870Size:1 Each
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Description
HPK1-IN-29 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-29 enhances the body's anti-tumor immunity. HPK1-IN-29 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 38) [1].
CAS Number
2699604-50-5
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-29.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CN=C2NC=C(C2=C1OC3=C(C=C(NC4=NCC5(CC5)CO4)C=C3F)F)C6=CC=C(F)C=C6
Molecular Formula
C26H18F3N5O2
Molecular Weight
489.45
References & Citations
[1]Jiang Lei, et al. Novel hpk1 inhibitors and methods of preparation and application thereof. Patent WO2021175270A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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