HDAC1/2 and CDK2-IN-1

HDAC1/2 and CDK2-IN-1

• CAS Number: 2418559-01-8
• UNSPSC Description: HDAC1/2 and CDK2-IN-1 (compound 14d) is a potent HDAC1, HDAC2 and CDK2 dual inhibitor, with IC50 values of 70.7, 23.1 and 0.80 μM, respectively. HDAC1/2 and CDK2-IN-1 can block the cell cycle and induce apoptosis. HDAC1/2 and CDK2-IN-1 exhibits desirable in vivo antitumor activity[1].
• Target Antigen: Apoptosis; CDK; HDAC
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hdac1-2-and-cdk2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=CC=C1N)C2=CC=C(CN3C=NC4=C(NC5=CC=C(C)C=C5)N=C(Cl)N=C34)C=C2
• Molecular Weight: 483.95
• References & Citations: [1]Yun F, Cheng C, Ullah S, Yuan Q. Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer. Eur J Med Chem. 2020;198:112322.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported