VEGFR2/HDAC1-IN-1

VEGFR2/HDAC1-IN-1

• CAS Number: 3024922-89-9
• UNSPSC Description: VEGFR2/HDAC1-IN-1 (compound 13) is a potent VEGFR-2/HDAC dual inhibitor, with IC50s of 57.83 nM and 9.82 nM, respectively. VEGFR2/HDAC1-IN-1 arrests the cell cycle at the S and G2 phases, and induces apoptosis in HeLa cells. VEGFR2/HDAC1-IN-1 exhibits anti-angiogenic effect[1].
• Target Antigen: Apoptosis; HDAC; VEGFR
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vegfr2-hdac1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C(NC)=O)C(C=C2)=C(O1)C=C2OC3=NC=NC4=CC(OC)=C(OCCCCCCC(NO)=O)C=C43
• Molecular Weight: 522.55
• References & Citations: [1]Gao Y, et, al. Design, synthesis and biological evaluation of VEGFR-2/HDAC dual inhibitors as multitargeted antitumor agents based on fruquintinib and vorinostat. RSC Adv. 2023 Sep 27;13(41):28462-28480.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported