HDAC1/CDK7-IN-1

HDAC1/CDK7-IN-1

• CAS Number: 2987905-95-1
• UNSPSC Description: HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].
• Target Antigen: Apoptosis; CDK; HDAC
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hdac1-cdk7-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC(NC(CCCCCCC(NO)=O)=O)=CC=C1)NC2=CC(NC3=NC(C4=CNC5=C4C=CC=C5)=C(Cl)C=N3)=CC=C2
• Molecular Weight: 626.10
• References & Citations: [1]Yao Chen, et al. Discovery of a Dual-Target Inhibitor of CDK7 and HDAC1 That Induces Apoptosis and Inhibits Migration in Colorectal Cancer. ChemMedChem. 2023 Oct 11:e202300281.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported