c-Met/HDAC-IN-2

c-Met/HDAC-IN-2

• CAS Number: 2740495-53-6
• UNSPSC Description: c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance[1].
• Target Antigen: Apoptosis; c-Met/HGFR; HDAC
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/c-met-hdac-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NN(C2=CC=CC=C2)C=CC1=O)NC3=CC=C(OC4=CC=NC5=CC(OCCCCCCC(NO)=O)=C(OC)C=C45)C=C3
• Molecular Weight: 623.66
• References & Citations: [1]Hu H, Chen F, Dong Y, et al. Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors. Eur J Med Chem. 2020;204:112651.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported