c-Met/HDAC-IN-4

c-Met/HDAC-IN-4

• UNSPSC Description: c-Met/HDAC-IN-4 is a dual inhibitor of c-Met/HDAC. The IC50 value of c-Met/HDAC-IN-4 for c-Met is 28.92 nM. c-Met/HDAC-IN-4 can induce G0/G1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells, and it inhibits the proliferation and invasion of breast cancer cell lines[1].
• Target Antigen: Apoptosis; c-Met/HGFR; HDAC
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/c-met-hdac-in-4.html
• Smiles: NC1=CC=CC=C1NC(/C=C/C2=CC=C(CN3CCN(C4=CC=C(N=NN5C(C6=CC=C(N=CC=C7)C7=C6)C)C5=C4)CC3)C=C2)=O
• Molecular Weight: 608.73
• References & Citations: [1]Wang Z, et al. Design and Synthesis of c-Met and HDAC Dual Inhibitors for the Treatment of Breast Cancer[J]. ACS Medicinal Chemistry Letters, 2024.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported