RORγt inhibitor 1

RORγt inhibitor 1

• CAS Number: 1561770-72-6
• UNSPSC Description: RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC50 value of 1 nM.
• Target Antigen: ROR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/rorγt-inhibitor-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H]1CCN(C[C@H]1O)C2=NN(C3=CC=CC(F)=C32)C(C4=C(C=CC=C4Cl)C5CC5)=O)O
• Molecular Weight: 457.88
• References & Citations: [1]Zhang H, et al. Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases. ACS Med Chem Lett. 2020 Jan 9;11(2):114-119.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported