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B-Raf IN 6

CAT: 0804-HY-142830Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142830Size:1 Each
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Description
B-Raf IN 6 (compound 2c) is a potent inhibitor of protein kinase B-Raf with an IC50 of 1.7 nM. B-Raf IN 6 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].
CAS Number
2648698-34-2
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-raf-in-6.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(F)=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C5NCCCC5)=N3)=C2F)=O
Molecular Formula
C24H21F3N6O2S2
Molecular Weight
546.59
References & Citations
[1]Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65 (2) :1552-1566.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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