Lp-PLA2-IN-4

CAT: 0804-HY-142669Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-142669Size:1 Each
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Description
Lp-PLA2-IN-4 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) . Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-4 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2021228159A1, compound 38) [1].
CAS Number
[2738877-91-1]
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lp-pla2-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1N2C(N3C[C@@H](OCC3)C2)=CC(OCC4=CC(F)=C(C(F)=C4)OC5=CC(C(F)(F)F)=CC=C5)=N1
Molecular Formula
C23H18F5N3O4
Molecular Weight
495.40
References & Citations
[1]Zhenhua Gu, et al. Bridging cyclic pyrimidinones, methods of preparation thereof, compositions thereof and uses. Patent WO2021228159A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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