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Lp-PLA2-IN-10

CAT: 0804-HY-142778Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142778Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lp-PLA2-IN-10 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) . Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-10 has the potential for the research of neurodegenerative-related diseases such as Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), or cardiovascular diseases including atherosclerosis (extracted from patent WO2022001881A1, compound 4) [1].
CAS Number
2756855-45-3
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lp-pla2-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(C2=C3N(CCN13)CCO2)OCC4=CC(F)=C(C(F)=C4)OC5=CC(C(F)(F)F)=NC=C5
Molecular Formula
C21H15F5N4O4
Molecular Weight
482.36
References & Citations
[1]Zhenhua Gu, et al. Bridging cyclic pyrimidinones, methods of preparation thereof, compositions thereof and uses. Patent WO2022001881A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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