Thalidomide-benzo

• Description :

  Thalidomide-benzo hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-benzo can be connected to the ligand for protein by a linker to form PROTACs[1].

• CAS Number :

  [458151-34-3]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/thalidomide-benzo.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1NC(C(CC1)N2C(C3=CC4=C(C=C3C2=O)C=CC=C4)=O)=O

• Molecular Formula :

  C17H12N2O4

• Molecular Weight :

  308.29

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-994.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon