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Thalidomide-methylpyrrolidine

CAT: 0804-HY-159597Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159597Size:1 Each
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Description
Thalidomide-methylpyrrolidine is a ligand for E3 ubiquitinase. Thalidomide-methylpyrrolidine can be used to synthesize CW-3308.
CAS Number
2616540-84-0
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-methylpyrrolidine.html
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C4C(CN(C)C4)=C3)=O
Molecular Formula
C16H15N3O4
Molecular Weight
313.31
References & Citations
[1]Wang C, et al. Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9. J Med Chem. 2024 Aug 22;67 (16) :14125-14154.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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