Biotin-Thalidomide

• Description :

  Biotin-Thalidomide is a biotin-conjugated Thalidomide (HY-14658) for binding to CRBN. Biotin-Thalidomide can be used to synthesize PROTAC[1] .

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/biotin-thalidomide.html

• Purity :

  99.65

• Solubility :

  Methanol : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(OCC(NCCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]3[C@]4([H])[C@](NC(N4)=O)([H])CS3)=O)=O)=O)=O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O

• Molecular Formula :

  C44H64N8O13S

• Molecular Weight :

  945.09

• References & Citations :

  [1]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14 (5) :431-441.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [2230857-87-9]