Tz-Thalidomide

• Description:

  Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase) . Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2) . Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Epigenetic Reader Domain; Molecular Glues; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tz-thalidomide.html

• Purity:

  98.60

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C (CCCCCOC1=C (C (N (C2CCC (NC2=O) =O) C3=O) =O) C3=CC=C1) NCC (C=C4) =CC=C4C5=NN=C (C) N=N5

• Molecular Formula:

  C29H29N7O6

• Molecular Weight:

  571.58

• Precautions:

  H315, H319

• References & Citations:

  [1]Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2 (12) :927-934.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  2087490-42-2