Thalidomide-d4

• Description:

  Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H360

• Target:

  Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Autophagy; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Inflammation/Immunology

• Purity:

  98.71

• Solubility:

  10 mM in DMSO|DMF : ≥ 12mg/mL|DMSO : ≥ 12mg/mL

• Smiles:

  O=C1N (C (CC2) C (NC2=O) =O) C (C3=C1C ([2H]) =C ([2H]) C ([2H]) =C3[2H]) =O

• Molecular Formula:

  C13H6D4N2O4

• Molecular Weight:

  262.26

• Precautions:

  H301, H360

• References & Citations:

  [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.|[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  1219177-18-0