Thalidomide-d4

• Description :

  Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H360

• Target :

  Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Inflammation/Immunology

• Purity :

  98.71

• Solubility :

  10 mM in DMSO|DMF : ≥ 12mg/mL|DMSO : ≥ 12mg/mL

• Smiles :

  O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O

• Molecular Formula :

  C13H6D4N2O4

• Molecular Weight :

  262.26

• Precautions :

  H301, H360

• References & Citations :

  [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.|[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon

• CAS Number :

  [1219177-18-0]