Thalidomide-d4

CAT: 0804-HY-14658S-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-14658S-01Size:500 µg
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Description
Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].
CAS Number
[1219177-18-0]
UNSPSC
12352005
Hazard Statement
H301, H360
Target
Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Purity
98.71
Solubility
10 mM in DMSO|DMF : ≥ 12mg/mL|DMSO : ≥ 12mg/mL
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O
Molecular Formula
C13H6D4N2O4
Molecular Weight
262.26
Precautions
H301, H360
References & Citations
[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.|[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Cereblon

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