Thalidomide-pyrrolidine

• Description:

  Thalidomide-pyrrolidine is an E3 ligase ligand. Thalidomide-pyrrolidine can be used for synthesis of PROTAC ARD-1676 (HY-156111) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319

• Target:

  Ligands for E3 Ligase

• Related Pathways:

  PROTAC

• Field of Research:

  Others

• Smiles:

  O=C1NC(C(CC1)N2C(C3=C(C2=O)C=C(CNC4)C4=C3)=O)=O

• Molecular Formula:

  C15H13N3O4

• Molecular Weight:

  299.28

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations:

  [1]Xiang W, et al. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. J Med Chem. 2023 Sep 28;66 (18) :13280-13303.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  [2616540-83-9]