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GNE-555

CAT: 0804-HY-13847Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13847Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-555 is a selective, metabolically stable mTOR inhibitor (Ki=1.5 nM) that also has good oral bioavailability. GNE-555 exhibits antiproliferative activity on PC3 and MCF-7 cells and can be used in cancer research[1][2].
CAS Number
1428902-71-9
UNSPSC
12352005
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-555.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(C[C@]4([H])CC[C@@]5([H])N4C6COC6)C5=N2)C=C1)NCC
Molecular Formula
C26H34N6O3
Molecular Weight
478.59
References & Citations
[1]Estrada AA, et al. Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR) . J Med Chem. 2013 Apr 11;56 (7) :3090-101.|[2]Huang G, et al. Applications of oxetanes in drug discovery and medicinal chemistry. Eur J Med Chem. 2023 Dec 5;261:115802.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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