GNE-555

• Description :

  GNE-555 is a selective, metabolically stable mTOR inhibitor (Ki=1.5 nM) that also has good oral bioavailability. GNE-555 exhibits antiproliferative activity on PC3 and MCF-7 cells and can be used in cancer research[1][2].

• UNSPSC :

  12352005

• Target :

  MTOR

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/gne-555.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(C[C@]4([H])CC[C@@]5([H])N4C6COC6)C5=N2)C=C1)NCC

• Molecular Formula :

  C26H34N6O3

• Molecular Weight :

  478.59

• References & Citations :

  [1]Estrada AA, et al. Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR) . J Med Chem. 2013 Apr 11;56 (7) :3090-101.|[2]Huang G, et al. Applications of oxetanes in drug discovery and medicinal chemistry. Eur J Med Chem. 2023 Dec 5;261:115802.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1428902-71-9]