GNE-555

• Description:

  GNE-555 is a selective, metabolically stable mTOR inhibitor (Ki=1.5 nM) that also has good oral bioavailability. GNE-555 exhibits antiproliferative activity on PC3 and MCF-7 cells and can be used in cancer research[1][2].

• UNSPSC:

  12352005

• Target:

  MTOR

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gne-555.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (NC1=CC=C (C2=NC (N3[C@@H] (C) COCC3) =C (C[C@]4 ([H]) CC[C@@]5 ([H]) N4C6COC6) C5=N2) C=C1) NCC

• Molecular Formula:

  C26H34N6O3

• Molecular Weight:

  478.59

• References & Citations:

  [1]Estrada AA, et al. Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR) . J Med Chem. 2013 Apr 11;56 (7) :3090-101.|[2]Huang G, et al. Applications of oxetanes in drug discovery and medicinal chemistry. Eur J Med Chem. 2023 Dec 5;261:115802.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1428902-71-9