GNE-064

CAT: 0804-HY-149026-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-149026-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis[1].

CAS Number

1997321-20-6

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/gne-064.html

Concentration

10mM

Purity

99.65

Solubility

DMSO : ≥ 125 mg/mL

Smiles

CC(N1[C@H](C)CN(C2=CC(C3=CC=CC=C3O)=NN=C2N)CC1)=O

Molecular Formula

C17H21N5O2

Molecular Weight

327.38

References & Citations

[1]Taylor AM, et al. GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J Med Chem. 2022 Aug 5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-114965-01	TP-064
HY-10499-01	PH-064
HY-10499A	PH-064 (tetra (hydrochloride) )
HY-175602	TM-04-064-02
HY-175448	GNE-1567
HY-15883-01	GNE-900
HY-107498-01	GNE-8324
HY-141551-01	GNE-274
HY-107409-01	GNE 5729
HY-19775-01	GNE-6468

Alternative Products

Catalog	Name
BA4693-50	GNE-064
BA4814-5	TP-064
FID30620-01	TP 064
MBS5755370	PH-064

GNE-064

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