GNE-555

• Target:

  MTOR

• Related Pathways:

  PI3K/Akt/mTOR signaling

• Bioactivity:

  GNE-555, a selective and metabolically stable mTOR inhibitor (K i=1.5 nM), demonstrates good oral bioavailability and antiproliferative activity on PC3 and MCF-7 cells, making it suitable for cancer research [1] [2].

• Smiles:

  C[C@@H]1N (C2=C3C ([C@@]4 (N ([C@] (C3) (CC4) [H]) C5COC5) [H]) =NC (=N2) C6=CC=C (NC (NCC) =O) C=C6) CCOC1

• Molecular Formula:

  C26H34N6O3

• Molecular Weight:

  478.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1428902-71-9