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DGN462

CAT: 0804-HY-101150-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101150-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML) . DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs) [1].
CAS Number
1394079-41-4
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dgn462.html
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@](CC3=C2C=CC=C3)([H])CNC4=CC(OCC5=CC(N(CC(C)(S)C)CCOCCOCCOC)=CC(COC6=C(OC)C=C7C(N8[C@](CC9=C8C=CC=C9)([H])C=NC7=C6)=O)=C5)=C(OC)C=C14
Molecular Formula
C53H59N5O9S
Molecular Weight
942.13
References & Citations
[1]Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104 (8) :1633-1639.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported

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