AV-412

• Description:

  AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

• Product Name Alternative:

  MP412

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AV-412.html

• Concentration:

  10mM

• Purity:

  99.17

• Solubility:

  DMSO : ≥ 28 mg/mL

• Smiles:

  O=S (C1=CC=C (C) C=C1) (O) =O.C=CC (NC2=CC3=C (NC4=CC=C (F) C (Cl) =C4) N=CN=C3C=C2C#CC (N5CCN (C) CC5) (C) C) =O.O=S (C6=CC=C (C) C=C6) (O) =O

• Molecular Formula:

  C41H44ClFN6O7S2

• Molecular Weight:

  851.41

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Suzuki T, et al. Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98 (12) :1977-84.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  EGFR/ErbB1/HER1; ErbB2/HER2

• Citation 01:

  Cancer Med. 2024 May;13 (10) :e7083.|Nature. 2025 Nov 26.|Proc Natl Acad Sci U S A. 2019 Feb 19;116 (8) :2996-3005. |Sci Data. 2024 Sep 19;11 (1) :1024.|Science. 2017 Dec 1;358 (6367) :eaan4368.

• CAS Number:

  451493-31-5