17-AEP-GA

• Description :

  17-AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. ADCs Toxin[1].

• CAS Number :

  [75747-23-8]

• UNSPSC :

  12352203

• Target :

  ADC Payload; HSP

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/17-aep-ga.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C(NCCN1CCCC1)=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(C)\C3=O)C=C(N3)C2=O

• Molecular Formula :

  C34H50N4O8

• Molecular Weight :

  642.78

• References & Citations :

  [1]Katarzyna Miekus, et al. 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. Oncol Rep. 2012 Nov;28 (5) :1903-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  HSP90; Traditional Cytotoxic Agents