GA 0113

CAT: 0804-HY-167886Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-167886Size:1 Each
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Description
GA 0113 is a potent and orally active angiotensin II (Ang II) AT1-receptor antagonist. GA 0113 inhibits the Ang II (HY-13948) -induced pressor response with ID50 of 0.032 mg/kg and dose-dependently increases plasma renin activity for 48 h[1].
CAS Number
[200639-61-8]
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ga-0113.html
Smiles
O=S(NC1=C(C2=NC3=C(C=C2)C=C(CN4C5=NC(C)=CC(C)=C5N=C4CC)C=C3)C=CC=C1)(C(F)(F)F)=O
Molecular Formula
C27H24F3N5O2S
Molecular Weight
539.57
References & Citations
[1]Ebisu H, et al. Pharmacologic profiles of GA0113, a novel quinoline derivative angiotensin II AT1-receptor antagonist. J Cardiovasc Pharmacol. 1999 Oct;34 (4) :526-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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