AEP-IN-2

CAT: 0804-HY-153986-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-153986-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AEP-IN-2 is an asparagine endopeptidase (AEP) inhibitor via block AEP cleavage of APP and Tau. AEP-IN-2 has oral activity and decreases Aβ40 and Aβ42 and p-Tau levels [1].

CAS Number

2565572-83-8

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aep-in-2.html

Purity

99.13

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCC1=C(N2CCOCC2)C3=NON=C3C(NC4=NN=C(NC)S4)=C1

Molecular Formula

C14H17N7O3S

Molecular Weight

363.39

References & Citations

[1]Zhengjiang Qian, et al. Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice. Neuropsychopharmacology. 2023.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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