AEP-IN-2

• Description :

  AEP-IN-2 is an asparagine endopeptidase (AEP) inhibitor via block AEP cleavage of APP and Tau. AEP-IN-2 has oral activity and decreases Aβ40 and Aβ42 and p-Tau levels [1].

• UNSPSC :

  12352005

• Target :

  Cathepsin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/aep-in-2.html

• Purity :

  99.13

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OCC1=C(N2CCOCC2)C3=NON=C3C(NC4=NN=C(NC)S4)=C1

• Molecular Formula :

  C14H17N7O3S

• Molecular Weight :

  363.39

• References & Citations :

  [1]Zhengjiang Qian, et al. Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice. Neuropsychopharmacology. 2023.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2565572-83-8]