17-DMAP-GA

CAT: 0804-HY-136312Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-136312Size:1 Each
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Description
17-DMAP-GA, a Geldanamycin (HY-15230) analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities[1][2].
CAS Number
[169521-68-0]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/17-dmap-ga.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCCNC(C(C=C1NC(/C(C)=C/C=C\[C@@H]2OC)=O)=O)=C(C[C@H](C[C@@H]([C@@H]([C@H](/C=C([C@@H]2OC(N)=O)\C)C)O)OC)C)C1=O
Molecular Formula
C33H50N4O8
Molecular Weight
630.77
References & Citations
[1]Jurczyszyn A, et al. Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor. J Cancer. 2014;5 (6) :480-490. Published 2014 May 31.|[2]Tian ZQ, et al. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004;12 (20) :5317-5329.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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