BCN-PEG4-OH

• UNSPSC Description:

  BCN-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG4-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bcn-peg4-oh.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]12[C@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCO)=O

• Molecular Weight:

  369.45

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported