BCN-PEG4-hydrazide

CAT: 0804-HY-133438-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-133438-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCN-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcn-peg4-hydrazide.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
[H][C@@]12[C@@](CCC#CCC2)([H])[C@H]1COC(NCCOCCOCCOCCOCCC(NN)=O)=O
Molecular Formula
C22H37N3O7
Molecular Weight
455.55
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

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