APN-PEG4-BCN

• Description:

  APN-PEG4-BCN is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. APN-PEG4-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC:

  12352203

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/apn-peg4-bcn.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC#CC1=CC=C (NC (CCOCCOCCOCCOCCNC (OC[C@@H]2[C@]3 ([H]) [C@@]2 ([H]) CCC#CCC3) =O) =O) C=C1

• Molecular Formula:

  C31H39N3O7

• Molecular Weight:

  565.66

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Cleavable Linker