APN-PEG4-BCN

• Description :

  APN-PEG4-BCN is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. APN-PEG4-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC :

  12352203

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/apn-peg4-bcn.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC#CC1=CC=C(NC(CCOCCOCCOCCOCCNC(OC[C@@H]2[C@]3([H])[C@@]2([H])CCC#CCC3)=O)=O)C=C1

• Molecular Formula :

  C31H39N3O7

• Molecular Weight :

  565.66

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker