BCN-PEG4-alkyne

• Description:

  BCN-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN-PEG4-alkyne is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bcn-peg4-alkyne.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@@]12[C@@] (CCC#CCC2) ([H]) [C@H]1COC (NCCOCCOCCOCCOCC#C) =O

• Molecular Formula:

  C22H33NO6

• Molecular Weight:

  407.50

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PEG Linkers