BCN-OH

• Description:

  BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps[1].

• Product Name Alternative:

  Endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/bcn-oh.html

• Purity:

  99.40

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  [H][C@]12[C@@]([H])([C@@H]2CO)CCC#CCC1

• Molecular Formula:

  C10H14O

• Molecular Weight:

  150.22

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Li Z, et al. Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function. Chem Res Toxicol. 2019 Mar 18;32 (3) :526-534.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [1263166-90-0]