BCN-OH

CAT: 0804-HY-W111141-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W111141-01Size:100 mg
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Description
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps[1].
CAS Number
[1263166-90-0]
Product Name Alternative
Endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bcn-oh.html
Purity
99.40
Solubility
DMSO : ≥ 100 mg/mL
Smiles
[H][C@]12[C@@]([H])([C@@H]2CO)CCC#CCC1
Molecular Formula
C10H14O
Molecular Weight
150.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Li Z, et al. Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function. Chem Res Toxicol. 2019 Mar 18;32 (3) :526-534.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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