EUK-189

• Description :

  EUK-189 is a synthetic superoxide dismutase (SOD) and catalase mimetic. EUK-189 can block oxygen/glucose deprivation (OGD) -induced ERK1/2 dephosphorylation, ATP depletion and eliminate ROS production. EUK-189 exhibits neuroprotective effect and can inhibit delayed radiation injury. EUK-189 can be used for the research of neurological disease, such as ischemic stroke[1][2].

• UNSPSC :

  12352100

• Target :

  ERK; Reactive Oxygen Species (ROS) ; SOD

• Related Pathways :

  Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  CC([O-][Mn+3]12([N]3=CC4=CC=CC(OCC)=C4[O-]2)[N](CC3)=CC5=C(C(OCC)=CC=C5)[O-]1)=O

• Molecular Formula :

  C22H25MnN2O6

• Molecular Weight :

  468.38

• References & Citations :

  [1]Zhou M, et al. Superoxide dismutase/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus. J Neurochem. 2007 Dec;103 (6) :2212-23.|[2]Rosenthal RA, et al. Salen Mn complexes mitigate radiation injury in normal tissues. Anticancer Agents Med Chem. 2011 May 1;11 (4) :359-72.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  ERK1; ERK2

• CAS Number :

  [186350-27-6]