EUK-189

CAT: 0804-HY-19382Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19382Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EUK-189 is a synthetic superoxide dismutase (SOD) and catalase mimetic. EUK-189 can block oxygen/glucose deprivation (OGD) -induced ERK1/2 dephosphorylation, ATP depletion and eliminate ROS production. EUK-189 exhibits neuroprotective effect and can inhibit delayed radiation injury. EUK-189 can be used for the research of neurological disease, such as ischemic stroke[1][2].
CAS Number
[186350-27-6]
UNSPSC
12352100
Target
ERK; Reactive Oxygen Species (ROS) ; SOD
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC([O-][Mn+3]12([N]3=CC4=CC=CC(OCC)=C4[O-]2)[N](CC3)=CC5=C(C(OCC)=CC=C5)[O-]1)=O
Molecular Formula
C22H25MnN2O6
Molecular Weight
468.38
References & Citations
[1]Zhou M, et al. Superoxide dismutase/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus. J Neurochem. 2007 Dec;103 (6) :2212-23.|[2]Rosenthal RA, et al. Salen Mn complexes mitigate radiation injury in normal tissues. Anticancer Agents Med Chem. 2011 May 1;11 (4) :359-72.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
ERK1; ERK2

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