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EUK-134

CAT: 0804-HY-100594-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100594-01Size:5 mg
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Description
EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3].
CAS Number
81065-76-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/euk-134.html
Purity
98.27
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
COC1=CC=CC2=C1[O-][Mn+3]([Cl-])[O-]C(C(OC)=CC=C3)=C3/C=N/CC/N=C/2
Molecular Formula
C18H18ClMnN2O4
Molecular Weight
416.74
Precautions
H302, H315, H319, H335
References & Citations
[1]P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62 (11) :1664-6.|[2]Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43 (4) :528-34.|[3]Sreeja Purushothaman, et al. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420 (1-2) :185-94.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB

Chemical Information

Ethylbisiminomethylguaiacol manganese chloride

See also: Ethylbisiminomethylguaiacol manganese chloride (annotation moved to).

CAS Number81065-76-1
PubChem CID9823233
IUPAC Namemanganese(3+);2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate;chloride
Molecular FormulaC18H18ClMnN2O4
Molecular Weight416.7
Topological Polar Surface Area89.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count26
Formal Charge0
Complexity378
SMILES
COC1=CC=CC(=C1[O-])C=NCCN=CC2=C(C(=CC=C2)OC)[O-].[Cl-].[Mn+3]
InChI
InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3
InChIKey
YUZJJFWCXJDFOQ-UHFFFAOYSA-K
Chemical Structure
2D Structure
2D structure of Ethylbisiminomethylguaiacol manganese chloride
CAS: 81065-76-1
CID: 9823233
Formula: C18H18ClMnN2O4
MW: 416.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight416.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass416.033553
Monoisotopic Mass416.033553
Topological Polar Surface Area89.3 Ų
Heavy Atom Count26
Formal Charge0
Complexity378
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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