EUK-134

• Description:

  EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  NF-κB

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/euk-134.html

• Purity:

  98.27

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  COC1=CC=CC2=C1[O-][Mn+3]([Cl-])[O-]C(C(OC)=CC=C3)=C3/C=N/CC/N=C/2

• Molecular Formula:

  C18H18ClMnN2O4

• Molecular Weight:

  416.74

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62 (11) :1664-6.|[2]Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43 (4) :528-34.|[3]Sreeja Purushothaman, et al. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420 (1-2) :185-94.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NF-κB

• CAS Number:

  [81065-76-1]