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(E/Z) -CLH304a

CAT: 0804-HY-129636ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129636ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E/Z) -CLH304a (GABAB receptor antagonist 1) is a mixture of (E) -CLH304a and (Z) -CLH304a. (E) -CLH304a (CLH304a; HY-129636) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a inhibits Baclofen -induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptors[1][2].
CAS Number
797-17-1
Product Name Alternative
GABAB receptor antagonist 1
UNSPSC
12352005
Target
ERK; GABA Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-z-clh304a.html
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C(O)C(/C=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O
Molecular Formula
C18H24O4
Molecular Weight
304.38
References & Citations
[1]Chen LH, et al. Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med Chem Lett. 2014 May 27;5 (7) :742-7.|[2]Bing Sun, et al. A negative allosteric modulator modulates GABAB-receptor signalling through GB2 subunits. Biochem J. 2016 Mar 15;473 (6) :779-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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