(E/Z) -CLH304a

• Description:

  (E/Z) -CLH304a (GABAB receptor antagonist 1) is a mixture of (E) -CLH304a and (Z) -CLH304a. (E) -CLH304a (CLH304a; HY-129636) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM) . CLH304a inhibits Baclofen (HY-B0007) -induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptors[1][2].

• Product Name Alternative:

  GABAB receptor antagonist 1

• UNSPSC:

  12352005

• Target:

  ERK; GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/e-z-clh304a.html

• Solubility:

  DMSO : ≥ 200 mg/mL

• Smiles:

  O=C (O) C (/C=C/C1=CC (C (C) (C) C) =C (O) C (C (C) (C) C) =C1) =O

• Molecular Formula:

  C18H24O4

• Molecular Weight:

  304.38

• References & Citations:

  [1]Chen LH, et al. Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med Chem Lett. 2014 May 27;5 (7) :742-7.|[2]Bing Sun, et al. A negative allosteric modulator modulates GABAB-receptor signalling through GB2 subunits. Biochem J. 2016 Mar 15;473 (6) :779-87.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  797-17-1