UK-1

• Description:

  UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities[1]. UK-1 also inhibits HCV replication[2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H332-H319

• Target:

  HCV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/uk-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C2N=C(C3=C4N=C(C5=CC=CC=C5O)OC4=CC=C3)OC2=CC=C1)OC

• Molecular Formula:

  C22H14N2O5

• Molecular Weight:

  386.36

• Precautions:

  P261-P264-P270-P271-P280-P304+P340-P305+P351+P338-P330-P501

• References & Citations:

  [1]Ueki M, et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) . 1993 Jul;46 (7) :1089-94.|[2]Ward DN, et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24 (2) :609-12.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  151271-53-3