UK-78282

• Description:

  UK-78282 is a selective Kv1.3 voltage-gated potassium channel inhibitor with an IC50 of 200 nM. UK-78282 also inhibit Kv1.4 potassium channel. UK-78282 can inhibit human T cell activation[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H319-H410

• Target:

  Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Inflammation/Immunology

• Smiles:

  COC1=CC=C(CCCN2CCC(COC(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C=C1

• Molecular Formula:

  C29H35NO2

• Molecular Weight:

  429.59

• Precautions:

  P264-P273-P280-P305+P351+P338-P391-P501

• References & Citations:

  [1]Hanson DC, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126 (8) :1707-16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Voltage-gated potassium channel

• CAS Number:

  191217-42-2