UK-78282

• Description :

  UK-78282 is a selective Kv1.3 voltage-gated potassium channel inhibitor with an IC50 of 200 nM. UK-78282 also inhibit Kv1.4 potassium channel. UK-78282 can inhibit human T cell activation[1].

• CAS Number :

  [191217-42-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H319-H410

• Target :

  Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Inflammation/Immunology

• Smiles :

  COC1=CC=C(CCCN2CCC(COC(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C=C1

• Molecular Formula :

  C29H35NO2

• Molecular Weight :

  429.59

• Precautions :

  P264-P273-P280-P305+P351+P338-P391-P501

• References & Citations :

  [1]Hanson DC, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126 (8) :1707-16.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Voltage-gated potassium channel