UK-78282

CAT: 0804-HY-113964Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-113964Size:1 Each
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Description
UK-78282 is a selective Kv1.3 voltage-gated potassium channel inhibitor with an IC50 of 200 nM. UK-78282 also inhibit Kv1.4 potassium channel. UK-78282 can inhibit human T cell activation[1].
CAS Number
[191217-42-2]
UNSPSC
12352005
Hazard Statement
H319-H410
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Smiles
COC1=CC=C(CCCN2CCC(COC(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C=C1
Molecular Formula
C29H35NO2
Molecular Weight
429.59
Precautions
P264-P273-P280-P305+P351+P338-P391-P501
References & Citations
[1]Hanson DC, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126 (8) :1707-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel

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